KRAS Mutation and RASopathies

**What it means:** KRAS is one of the most commonly mutated genes in cancer. "RASopathies" are a group of genetic conditions caused by mutations in the RAS signaling pathway (which includes genes like KRAS, BRAF, RAF1, NRAS, etc.). These are developmental disorders that share overlapping features with MHS — intellectual disability, facial dysmorphism, heart defects, and growth delays. **Why this connects to MHS:** Understanding RASopathies helps explain why MEF2C deficiency sometimes looks like other genetic syndromes. There's also therapeutic overlap — drugs developed for RASopathies (like MEK inhibitors) might have potential for MHS treatment.