Explainers

Plain-English explanations of MEF2C research terms, concepts, and scientific mechanisms.

Gene Therapy Vector Optimisation (for AAV packaging)

**What it means:** The MEF2C gene is relatively large — about 12-13 kilobases (kb) of DNA. But the AAV vector can only carry about 4.7 kb of genetic material. So the UT Southwestern team had to "shrin...